财新传媒

Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment

2021年03月04日 14:28 来源于 财新网
可以听文章啦!

  【财新网】

  Science 12 Feb 2021:

  Vol. 371, Issue 6530, eaax2537

  DOI: 10.1126/science.aax2537

  Brain organoids with Neanderthal genes

  The genomes of Neanderthals and modern humans are overall very similar. To understand the impact of genetic variants that are specific to modern humans, Trujillo et al. performed a genome-wide analysis to identify 61 coding variants in protein-coding genes. Identifying the gene encoding the RNA-binding protein NOVA1 as a top candidate for functional analyses, they introduced the archaic gene variant into human pluripotent stem cells and generated brain organoids. These organoids showed alterations in gene expression and splicing as well as morphology and synaptogenesis, suggesting that this method could be used to explore other genetic changes that underlie the phenotypic traits separating our species from extinct relatives.

版面编辑:许金玲

图片推荐

视听推荐

财新网主编精选版电邮 样例
财新网新闻版电邮全新升级!财新网主编精心编写,每个工作日定时投递,篇篇重磅,可信可引。
订阅